Rowley A H, Gonzalez-Crussi F, Shulman S T
Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois.
Rev Infect Dis. 1988 Jan-Feb;10(1):1-15. doi: 10.1093/clinids/10.1.1.
Kawasaki syndrome is an acute self-limited illness of young children that may result in significant cardiovascular sequelae in 20% of patients. The etiology is unknown, but clinical and epidemiologic features strongly suggest an infectious etiology. The incidence of coronary artery abnormalities has been dramatically reduced by administration of intravenous gamma-globulin in the acute phase of illness. This paper reviews the clinical, laboratory, etiologic, epidemiologic, cardiovascular, pathologic, and therapeutic aspects of Kawasaki syndrome. Discovery of the etiology of this disorder will enable more specific diagnostic tests and therapies to be developed.
川崎病是一种小儿急性自限性疾病，20%的患者可能会出现严重的心血管后遗症。病因不明，但临床和流行病学特征强烈提示为感染性病因。在疾病急性期静脉注射丙种球蛋白已显著降低了冠状动脉异常的发生率。本文综述了川崎病的临床、实验室检查、病因、流行病学、心血管、病理及治疗等方面。发现该疾病的病因将有助于开发更具特异性的诊断检测方法和治疗手段。
