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实施心源性死亡后器官捐献方案。

Implementing donation after cardiac death protocols.

作者信息

Fidler Suzanne A

出版信息

J Health Life Sci Law. 2008 Oct;2(1):123, 125-49.

PMID:19004299
Abstract

As organ transplantation becomes increasingly successful and the demand for organs outnumbers available organs, the transplantation community has revived the transplantation process of donation after cardiac death (DCD). In DCD donation, organ procurement begins once the donor's cardiopulmonary function ceases. This is in contrast to the more common practice of donation after brain death (DBD), where organ procurement begins once the donor is declared brain dead--even while the donor's cardiopulmonary function is artificially supported to perfuse and maintain the donor's organs. In January 2007, the Joint Commission required hospitals, in coordination with their Organ Procurement Organizations (OPO),* either to create donation after cardiac death policies or document efforts to formulate the policies and justifications for opting out. As DCD practice grows, legal and ethical issues surface. This article will discuss these legal and ethical issues, including determining a donor's death based on the irreversible cessation of cardiopulmonary function, procedures conducted on the donor for the benefit of the donee, informed consent and the surrogate decisionmaker, choosing appropriate DCD candidates, and conflicts of interest. This article will summarize general recommendations for donor candidate selection, consent and approval, withdrawal of life-sustaining measures, criteria for determining death, organ recovery, and financial considerations.

摘要

随着器官移植越来越成功,对器官的需求超过了可获得的器官数量,移植界重新启用了心脏死亡后捐赠(DCD)的移植程序。在DCD捐赠中,一旦供体的心肺功能停止,器官获取就开始了。这与脑死亡后捐赠(DBD)这种更常见的做法形成对比,在DBD中,一旦供体被宣布脑死亡,器官获取就开始——即使供体的心肺功能通过人工支持来灌注和维持供体的器官。2007年1月,联合委员会要求医院与其器官获取组织(OPO)协调,要么制定心脏死亡后捐赠政策,要么记录制定政策的努力以及选择不制定政策的理由。随着DCD实践的增加,法律和伦理问题浮出水面。本文将讨论这些法律和伦理问题,包括基于心肺功能不可逆停止来确定供体死亡、为受赠者利益对供体进行的程序、知情同意和替代决策者、选择合适的DCD候选人以及利益冲突。本文将总结关于供体候选人选择、同意和批准、维持生命措施的撤除、死亡判定标准、器官获取和财务考虑的一般建议。

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