Exley Christopher, Swarbrick Louise, Gherardi Rhomain K, Authier Francois-Jérôme
Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK.
Med Hypotheses. 2009 Feb;72(2):135-9. doi: 10.1016/j.mehy.2008.09.040. Epub 2008 Nov 11.
Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines. While a little is known of disease aetiology both conditions are characterised by an aberrant immune response, have a number of prominent symptoms in common and are coincident in many individuals. Herein, we have described a case of vaccine-associated chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating aluminium overload. This is the first report linking the latter with either of these two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in this individual. This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.
巨噬细胞性肌炎和慢性疲劳综合征是严重致残性疾病，可能由疫苗中含铝佐剂的不良反应引起。虽然对这两种疾病的病因了解甚少，但它们都具有异常免疫反应的特征，有许多共同的突出症状，且在许多个体中同时出现。在此，我们描述了一例在个体中出现的与疫苗相关的慢性疲劳综合征和巨噬细胞性肌炎，该个体表现出铝过载。这是将铝过载与这两种疾病中的任何一种联系起来的首例报告，并且认为 coincident（此处原文有误，推测应为“同时存在的”）铝过载在很大程度上导致了该个体这些疾病的严重程度。该病例突出了含铝佐剂相关的潜在危险，并且我们阐明了一种可能的机制，即涉及含铝佐剂的疫苗接种可能引发与包括慢性疲劳综合征和巨噬细胞性肌炎在内的自身免疫性疾病相关的免疫事件级联反应。
