哺乳动物大脑中神经元迁移的模式与意外情况。
Modes and mishaps of neuronal migration in the mammalian brain.
作者信息
Métin Christine, Vallee Richard B, Rakic Pasko, Bhide Pradeep G
机构信息
Institut du Fer à Moulin, Inserm Unité Mixte de Recherche-S 839, 75005 Paris, France, Department of Pathology, Columbia University, New York, New York 10032, USA.
出版信息
J Neurosci. 2008 Nov 12;28(46):11746-52. doi: 10.1523/JNEUROSCI.3860-08.2008.
Abstract
The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of this process to environmental and genetic factors. Here we discuss the role of cytoskeleton, motor proteins, and mechanisms of nuclear translocation in radial and tangential migration of neurons. We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans.
摘要
神经元在发育中的大脑中迁移到其适当位置的能力对大脑结构和功能至关重要。最近的研究阐明了神经元迁移的不同模式以及许多信号因子在协调迁移中的作用，以及这一过程对环境和遗传因素的脆弱性。在这里，我们讨论细胞骨架、运动蛋白的作用以及核转运机制在神经元径向和切向迁移中的作用。我们还将讨论这些以及其他对神经元正常迁移至关重要的事件如何被导致人类神经疾病的遗传和环境因素所破坏。
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本文引用的文献
1
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J Cell Sci. 2008 Oct 15;121(Pt 20):3476-86. doi: 10.1242/jcs.029454. Epub 2008 Sep 30.
2
Origins of cortical GABAergic neurons in the cynomolgus monkey.食蟹猴大脑皮质GABA能神经元的起源
Cereb Cortex. 2009 Feb;19(2):249-62. doi: 10.1093/cercor/bhn078. Epub 2008 May 13.
3
Distinct origin of GABA-ergic neurons in forebrain of man, nonhuman primates and lower mammals.人类、非人灵长类动物和低等哺乳动物前脑中γ-氨基丁酸能神经元的不同起源。
Coll Antropol. 2008 Jan;32 Suppl 1:9-17.
4
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Nat Rev Neurosci. 2008 Feb;9(2):110-22. doi: 10.1038/nrn2252.
5
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Brain Res. 2007 Nov 28;1182:11-25. doi: 10.1016/j.brainres.2007.08.088. Epub 2007 Sep 21.
7
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8
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J Cell Biol. 2007 Aug 13;178(4):583-94. doi: 10.1083/jcb.200610112. Epub 2007 Aug 6.
9
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Nat Neurosci. 2007 Aug;10(8):970-9. doi: 10.1038/nn1934. Epub 2007 Jul 8.
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