Métin Christine, Vallee Richard B, Rakic Pasko, Bhide Pradeep G
Institut du Fer à Moulin, Inserm Unité Mixte de Recherche-S 839, 75005 Paris, France, Department of Pathology, Columbia University, New York, New York 10032, USA.
J Neurosci. 2008 Nov 12;28(46):11746-52. doi: 10.1523/JNEUROSCI.3860-08.2008.
The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of this process to environmental and genetic factors. Here we discuss the role of cytoskeleton, motor proteins, and mechanisms of nuclear translocation in radial and tangential migration of neurons. We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans.
神经元在发育中的大脑中迁移到其适当位置的能力对大脑结构和功能至关重要。最近的研究阐明了神经元迁移的不同模式以及许多信号因子在协调迁移中的作用，以及这一过程对环境和遗传因素的脆弱性。在这里，我们讨论细胞骨架、运动蛋白的作用以及核转运机制在神经元径向和切向迁移中的作用。我们还将讨论这些以及其他对神经元正常迁移至关重要的事件如何被导致人类神经疾病的遗传和环境因素所破坏。
