神经系统中的表观遗传学
Epigenetics in the nervous system.
作者信息
Jiang Yan, Langley Brett, Lubin Farah D, Renthal William, Wood Marcelo A, Yasui Dag H, Kumar Arvind, Nestler Eric J, Akbarian Schahram, Beckel-Mitchener Andrea C
机构信息
Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA.
出版信息
J Neurosci. 2008 Nov 12;28(46):11753-9. doi: 10.1523/JNEUROSCI.3797-08.2008.
Abstract
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
摘要
越来越明显的是，表观遗传修饰是基因表达调控中的关键因素。就神经系统而言，表观遗传改变在一系列不同的过程中发挥作用，并与多种疾病有关。更全面地了解表观遗传调控所涉及的基本组成部分和潜在机制，可能会为许多神经和精神疾病带来新的治疗方法。
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