早期生活压力不断演变的神经生物学
The evolving neurobiology of early-life stress.
作者信息
Birnie Matthew T, Baram Tallie Z
机构信息
Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.
Department of Pediatrics, University of California, Irvine, Irvine, CA, USA; Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA, USA; Department of Neurology, University of California, Irvine, Irvine, CA, USA.
出版信息
Neuron. 2025 May 21;113(10):1474-1490. doi: 10.1016/j.neuron.2025.02.016. Epub 2025 Mar 17.
Abstract
Because early-life stress is common and constitutes a strong risk factor for cognitive and mental health disorders, it has been the focus of a multitude of studies in humans and experimental models. Yet, we have an incomplete understanding of what is perceived as stressful by the developing brain, what aspects of stress influence brain maturation, what developmental ages are particularly vulnerable to stress, which molecules mediate the effects of stress on brain operations, and how transient stressful experiences can lead to enduring emotional and cognitive dysfunctions. Here, we discuss these themes, highlight the challenges and progress in resolving them, and propose new concepts and avenues for future research.
摘要
由于早期生活压力很常见，并且是认知和精神健康障碍的一个强大风险因素，它一直是人类和实验模型众多研究的焦点。然而，我们对发育中的大脑所认为的压力源、压力的哪些方面会影响大脑成熟、哪些发育阶段特别容易受到压力影响、哪些分子介导压力对大脑运作的影响，以及短暂的压力经历如何导致持久的情绪和认知功能障碍等方面的理解并不完整。在此我们讨论这些主题，强调解决这些问题过程中的挑战和进展，并提出未来研究的新概念和途径。
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