慢性疼痛中的炎症和组蛋白修饰。
Inflammation and histone modification in chronic pain.
机构信息
Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, China.
出版信息
Front Immunol. 2023 Jan 13;13:1087648. doi: 10.3389/fimmu.2022.1087648. eCollection 2022.
Abstract
Increasing evidence suggests that epigenetic mechanisms have great potential in the field of pain. The changes and roles of epigenetics of the spinal cord and dorsal root ganglia in the chronic pain process may provide broad insights for future pain management. Pro-inflammatory cytokines and chemokines released by microglia and astrocytes, as well as blood-derived macrophages, play critical roles in inducing and maintaining chronic pain, while histone modifications may play an important role in inflammatory metabolism. This review provides an overview of neuroinflammation and chronic pain, and we systematically discuss the regulation of neuroinflammation and histone modifications in the context of chronic pain. Specifically, we analyzed the role of epigenetics in alleviating or exacerbating chronic pain by modulating microglia, astrocytes, and the proinflammatory mediators they release. This review aimed to contribute to the discovery of new therapeutic targets for chronic pain.
摘要
越来越多的证据表明，表观遗传机制在疼痛领域具有巨大的潜力。脊髓和背根神经节的表观遗传学变化和作用可能为未来的疼痛管理提供广泛的见解。小胶质细胞和星形胶质细胞释放的促炎细胞因子和趋化因子以及血液来源的巨噬细胞在诱导和维持慢性疼痛中起着关键作用，而组蛋白修饰可能在炎症代谢中发挥重要作用。本综述概述了神经炎症和慢性疼痛，并系统地讨论了神经炎症和组蛋白修饰在慢性疼痛背景下的调节。具体而言，我们分析了通过调节小胶质细胞、星形胶质细胞及其释放的促炎介质来减轻或加重慢性疼痛的表观遗传学作用。本综述旨在为慢性疼痛的新治疗靶点的发现做出贡献。
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