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叶酸：合适的剂量。

Folic acid: the right dose.

作者信息

Koren Gideon, Goh Y Ingrid, Klieger Chagit

出版信息

Can Fam Physician. 2008 Nov;54(11):1545-7.

PMID:19005123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2592326/
Abstract

ABSTRACTQUESTION The new Motherisk Guidelines suggest 5 mg/d of folic acid. Why was the dose increased? What is the time frame for taking such a dose?ANSWER Recent data from Ontario reveal that 40% of women of reproductive age still do not achieve therapeutic systemic levels of folate needed to prevent neural tube defects. Compliance is less than optimal among women using prenatal vitamins, rendering many women unprotected against neural tube defects. Taking a higher dose of folate will allow achievement of protective folate levels, even with partial compliance. Five mg of folate should be used daily several months before conception until the end of the first trimester.

摘要

摘要

问题

新的母亲风险指南建议叶酸剂量为每日5毫克。为何增加剂量？服用此剂量的时间范围是多久？

答案

安大略省的最新数据显示，40%的育龄妇女仍未达到预防神经管缺陷所需的叶酸治疗性全身水平。服用产前维生素的女性依从性欠佳，致使许多女性无法预防神经管缺陷。即使部分依从，服用更高剂量的叶酸也能达到保护性叶酸水平。应在受孕前数月至孕早期结束期间每日服用5毫克叶酸。

相似文献

1
Folic acid: the right dose.叶酸：合适的剂量。
Can Fam Physician. 2008 Nov;54(11):1545-7.
2
Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies.孕前补充叶酸和多种维生素用于神经管缺陷及其他叶酸敏感型先天性异常的一级和二级预防
J Obstet Gynaecol Can. 2015 Jun;37(6):534-52. doi: 10.1016/s1701-2163(15)30230-9.
3
Folic acid and prevention of neural tube defects.叶酸与神经管缺陷的预防
Can Fam Physician. 2008 Jan;54(1):36-8.
4
Folic Acid for the prevention of neural tube defects: recommendation statement.预防神经管缺陷的叶酸：推荐声明。
Am Fam Physician. 2010 Dec 15;82(12):1526-7.
5
[Folic acid should not be added automatically to bread].叶酸不应自动添加到面包中。
Ned Tijdschr Geneeskd. 2008 Jul 12;152(28):1569.
6
Strategies for Preventing Folate-Related Neural Tube Defects: Supplements, Fortified Foods, or Both?预防叶酸相关神经管缺陷的策略：补充剂、强化食品，还是两者皆用？
JAMA. 2017 Jan 10;317(2):144-145. doi: 10.1001/jama.2016.19894.
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Policy statement on folic acid and neural tube defects.关于叶酸和神经管缺陷的政策声明。
Genet Med. 2011 Jun;13(6):593-6. doi: 10.1097/GIM.0b013e31821d4188.
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Folic Acid for the prevention of neural tube defects.叶酸用于预防神经管缺陷。
Am Fam Physician. 2010 Dec 15;82(12):1533.
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Folic Acid Supplementation for Prevention of Neural Tube Defects.补充叶酸预防神经管缺陷
JAMA. 2017 Jan 10;317(2):222. doi: 10.1001/jama.2016.19767.
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[Folic acid fortification of bread recommendable].[面包强化叶酸值得推荐]。
Ned Tijdschr Geneeskd. 2008 Jul 12;152(28):1568.

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Development and Validation of the Brief Folate-Specific Food Frequency Questionnaire for Young Women's Diet Assessment.《用于年轻女性膳食评估的简明叶酸特异性食物频率问卷的编制与验证》。
Int J Environ Res Public Health. 2017 Dec 14;14(12):1574. doi: 10.3390/ijerph14121574.
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Folate and neural tube defects: The role of supplements and food fortification.叶酸与神经管缺陷：补充剂及食品强化的作用
Paediatr Child Health. 2016 Apr;21(3):145-54. doi: 10.1093/pch/21.3.145.
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Role of maternal vitamins in programming health and chronic disease.母体维生素在健康与慢性病编程中的作用。
Nutr Rev. 2016 Mar;74(3):166-80. doi: 10.1093/nutrit/nuv103. Epub 2016 Feb 16.
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High Folic Acid Intake during Pregnancy Lowers Body Weight and Reduces Femoral Area and Strength in Female Rat Offspring.孕期高叶酸摄入量会降低雌性大鼠后代的体重，并减小其股骨面积和强度。
J Osteoporos. 2013;2013:154109. doi: 10.1155/2013/154109. Epub 2013 May 27.
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Folic acid and human reproduction-ten important issues for clinicians.叶酸与人类生殖——临床医生需关注的十个重要问题
J Exp Clin Assist Reprod. 2011;8:2. Epub 2011 Aug 10.

本文引用的文献

1
Folate fortification and supplementation--are we there yet?叶酸强化与补充——我们做到了吗？
Reprod Toxicol. 2008 Aug;25(4):408-12. doi: 10.1016/j.reprotox.2008.04.010. Epub 2008 May 3.
2
RETIRED: Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies.已退休：孕前维生素/叶酸补充剂2007：叶酸与多种维生素补充剂联合使用预防神经管缺陷及其他先天性异常。
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3
Increasing folate supplementation for selected groups of Canadian women.增加对特定加拿大女性群体的叶酸补充量。
J Obstet Gynaecol Can. 2007 Dec;29(12):992-996. doi: 10.1016/S1701-2163(16)32690-1.
4
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.在叶酸强化时代，美国老年人中叶酸和维生素B-12状态与贫血、大细胞性贫血及认知障碍的关系
Am J Clin Nutr. 2007 Jan;85(1):193-200. doi: 10.1093/ajcn/85.1.193.
5
Does a high folate intake increase the risk of breast cancer?高叶酸摄入量会增加患乳腺癌的风险吗？
Nutr Rev. 2006 Oct;64(10 Pt 1):468-75. doi: 10.1301/nr.2006.oct.468-475.
6
Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis.产前补充多种维生素与先天性异常发生率：一项荟萃分析。
J Obstet Gynaecol Can. 2006 Aug;28(8):680-689. doi: 10.1016/S1701-2163(16)32227-7.
7
Quantifying the effect of folic acid.量化叶酸的作用。
Lancet. 2001 Dec 15;358(9298):2069-73. doi: 10.1016/s0140-6736(01)07104-5.
8
Minimum effective dose of folic acid for food fortification to prevent neural-tube defects.用于食品强化以预防神经管缺陷的叶酸最低有效剂量。
Lancet. 1997 Dec 6;350(9092):1666-9. doi: 10.1016/S0140-6736(97)07247-4.
9
Folate levels and neural tube defects. Implications for prevention.叶酸水平与神经管缺陷。预防的意义。
JAMA. 1995 Dec 6;274(21):1698-702. doi: 10.1001/jama.1995.03530210052030.
10
Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group.神经管缺陷的预防：医学研究委员会维生素研究结果。医学研究委员会维生素研究小组
Lancet. 1991 Jul 20;338(8760):131-7.