Department of Pharmacology, Therapeutics & Toxicology College of Medicine University of Lagos Lagos Nigeria.
Department of Pharmacology College of Medicine Lagos State University Lagos Nigeria.
Pharmacol Res Perspect. 2019 Feb 6;7(1):e00452. doi: 10.1002/prp2.452. eCollection 2019 Feb.
Birth defects are important causes of neonatal morbidity and mortality. A good understanding of the etiology is a vital step toward developing improved treatment and preventive strategies. We conducted an audit of medical records of newborns with birth abnormalities in a tertiary hospital over a 10-year period, using a Pro forma designed to collect information on obstetric history, antenatal history, sociodemographics of parents, and the type of birth abnormality. Of the 180 medical records reviewed, female babies were 92 (51.1%) and male babies were 86 (47.8%). The mean age of the fathers was 38.2 + 6.2, and mothers 31.8 + 4.9. Majority 115 (63.9%) of the mothers had records of acute illnesses, and 23 (12.8%) chronic illnesses during pregnancy. Unspecified febrile illness 44 (38.3%), malaria 40 (34.8%), typhoid 8 (6.9%), hypertension 13 (56.5%), pregestational diabetes 4 (17.4%), and HIV 3 (13.0%) were the commonest maternal pathologies. Most of the documented birth abnormalities were Down's syndrome 34 (15.2%); congenital hydrocephalus 32 (14.3%); acyanotic congenital heart defect 30 (13.4%); deformity of the digits 26 (11.6%); and ventricular septal defect 20 (8.9%). The prevalence of maternal pathologies calls for concern, as these may be implicated in birth defects, therefore should be further investigated in future studies.
出生缺陷是新生儿发病率和死亡率的重要原因。深入了解其病因是制定改善治疗和预防策略的关键步骤。我们对一家三级医院的 10 年间出生异常新生儿的病历进行了审核，使用了一份专门设计的表格来收集有关产科史、产前史、父母社会人口统计学和出生缺陷类型的信息。在审核的 180 份病历中，女婴 92 例（51.1%），男婴 86 例（47.8%）。父亲的平均年龄为 38.2 ± 6.2 岁，母亲为 31.8 ± 4.9 岁。115 例（63.9%）母亲有急性疾病记录，23 例（12.8%）有慢性疾病记录。44 例（38.3%）母亲有未指明的发热性疾病，40 例（34.8%）有疟疾，8 例（6.9%）有伤寒，13 例（56.5%）有高血压，4 例（17.4%）有妊娠前糖尿病，3 例（13.0%）有 HIV。最常见的母体病理是唐氏综合征 34 例（15.2%）；先天性脑积水 32 例（14.3%）；非发绀性先天性心脏病 30 例（13.4%）；指畸形 26 例（11.6%）；室间隔缺损 20 例（8.9%）。母体病理的发生率令人担忧，因为这些可能与出生缺陷有关，因此应该在未来的研究中进一步调查。
