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The polymorphisms of bovine cocaine- and amphetamine-regulated transcripts and their associations with cattle (Bos taurus) growth traits.

作者信息

Zhang Chun Lei, Chen Hong, Wang Yan Hong, Lan Xian Yong, Lei Chu Zhao, Fang Xing Tang

机构信息

College of Life Science, Xuzhou Normal University, Xuzhou, Jiangsu, P R China.

出版信息

J Biosci. 2008 Sep;33(3):365-70. doi: 10.1007/s12038-008-0056-1.

DOI:10.1007/s12038-008-0056-1
PMID:19005236
Abstract

We investigated the polymorphisms of bovine cocaine- and amphetamine-regulated transcripts (CART ). The coding and regulating regions of CART were screened in 7 cattle breeds by the single-stranded conformation polymorphism (SSCP) technique. The four loci (C1,C2, C3 and C4) studied were all polymorphic. Polymerase chain reaction (PCR) products representing different SSCP variants were sequenced and a total of 9 single-nucleotide polymorphisms (SNPs) were found. The associations between polymorphic loci and the growth traits of Nanyang cattle were analysed. The results indicated that genotype A1A1 of the C1 locus was associated with a higher body weight (P less than 0.05) than heterozygous A1B1. Genotype A2A2 of the C2 locus was associated with lower body weight and average daily weight gain (P < or = 0.001) than heterozygous A2B2. C3 and C4 loci had no significant effect on Nanyang cattle growth traits (P > 0.05).

摘要

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本文引用的文献

1
Enhance the efficiency of single-strand conformation polymorphism analysis by short polyacrylamide gel and modified silver staining.通过短聚丙烯酰胺凝胶和改良银染提高单链构象多态性分析的效率。
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3
CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight.
CART基因敲除小鼠存在胰岛素分泌受损和葡萄糖不耐受的情况，β细胞形态改变且体重增加。
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The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery.
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5
Transcriptional regulation of the CART promoter in CATH.a cells.CATH.a细胞中CART启动子的转录调控。
Brain Res Mol Brain Res. 2004 Jul 5;126(1):22-9. doi: 10.1016/j.molbrainres.2004.02.027.
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Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet.
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7
Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity.可卡因和苯丙胺调节转录基因假定启动子区域的测序以及与肥胖相关的多态性位点的鉴定。
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Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site.脑室内注射可卡因-安非他明调节转录肽可减少食物摄入量并改变后脑部位的运动行为。
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Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters.食物限制引起的季节性不适当体重：对雄性西伯利亚仓鼠下丘脑基因表达的影响
Endocrinology. 2001 Oct;142(10):4173-81. doi: 10.1210/endo.142.10.8454.
10
Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family.肥胖儿童中CART基因的突变筛查：鉴定出一种与静息能量消耗降低相关且在一个大家庭中与肥胖表型共分离的突变（Leu34Phe）
Diabetes. 2001 Sep;50(9):2157-60. doi: 10.2337/diabetes.50.9.2157.