Long-term seizure control after resection of supratentorial cavernomas: a retrospective single-center study in 53 patients.

OBJECTIVE

The goal of this study was to examine the long-term outcomes of 53 epilepsy patients who were surgically treated for supratentorial cavernomas in a single-center study and to assess both the duration of epilepsy and the resection of the hemosiderin rim for their prognostic relevance during extended follow-up.

METHODS

Fifty-three patients underwent microsurgical resection of radiologically diagnosed supratentorial cavernomas. For the outcome analysis, they were divided into 2 groups: Group A (33 patients) with a preoperative duration of epilepsy of less than 2 years, and Group B (20 patients) with a preoperative duration of epilepsy of 2 years or more. The natural history of the cavernomas, localization and size of the lesions, use of antiepileptic drugs, surgery timing, and technique (removal or not of the surrounding gliosis) were evaluated retrospectively. The outcome of epilepsy was based on Engel's classification and the International League Against Epilepsy classification.

RESULTS

After a mean follow-up period of 8.1 years, 45 (84.9%) of the 53 patients were free from disabling seizures (Engel Class I), including 37 patients (69.8%) who were completely free of postoperative seizures (Engel Class IA); 43 patients (81.1%) were categorized as International League Against Epilepsy Class 1. Outcome was statistically significantly improved in the patient subgroup of our study in which patients underwent a resection of the surrounding gliosis after a preoperative duration of epilepsy of less than 2 years (Group A). There was no mortality, and only minor postoperative neurological deficits occurred in 7.5% of patients.

CONCLUSION

In a long-term follow-up period, 84.9% of the patients in the study could be evaluated as Engel Class I. The analysis of outcome showed that patients benefited significantly from early surgery and excision of the hemosiderin rim.