Luk Keith D K, Ruan D K
The Department of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):504-10. doi: 10.1007/s00586-008-0748-0. Epub 2008 Nov 13.
Intervertebral disc transplantation was developed in a bipedal animal model through the stages of autograft, fresh allograft and fresh frozen allograft. Results showed that the allografts were able to survive through a deep freezing protocol and maintain cell viability after transplantation without significant immunoreaction. Although degeneration of the allograft appeared to be inevitable, it was able to maintain stability and mobility of the functional spinal unit. These findings were similarly reproduced in the human clinical trial with excellent mid-term clinical results at 5 years. The process of evolution and findings were summarized in this review.
椎间盘移植是在双足动物模型中通过自体移植、新鲜同种异体移植和新鲜冷冻同种异体移植等阶段发展起来的。结果表明，同种异体移植物能够通过深度冷冻方案存活，并在移植后保持细胞活力，且无明显免疫反应。尽管同种异体移植物的退变似乎不可避免，但它能够维持功能性脊柱单元的稳定性和活动度。这些发现同样在人类临床试验中得到重现，5年的中期临床结果优异。本综述总结了其发展过程和研究结果。
