Brazel Christopher S
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama, 35487-0203, USA.
Pharm Res. 2009 Mar;26(3):644-56. doi: 10.1007/s11095-008-9773-2. Epub 2008 Nov 13.
This paper reviews the design and development of magnetothermally-triggered drug delivery systems, whereby magnetic nanoparticles are combined with thermally-activated materials. By combining superparamagnetic nanoparticles with lower critical solution temperature (LCST) polymers, an alternating current (AC) magnetic field can be used to trigger localized heating in vivo, which in turn causes a phase change in the host polymer to allow diffusion and release of drugs. The use of magnetic nanoparticles for biomedical applications is reviewed, as well as the design of thermally-activated polymeric systems. Current research on externally-triggered delivery is highlighted, with a focus on the design and challenges in developing magnetothermally-activated systems.
本文综述了磁热触发药物递送系统的设计与开发，该系统是将磁性纳米颗粒与热激活材料相结合。通过将超顺磁性纳米颗粒与低临界溶液温度（LCST）聚合物相结合，交变电流（AC）磁场可用于在体内触发局部加热，进而导致主体聚合物发生相变，从而使药物得以扩散和释放。文中综述了磁性纳米颗粒在生物医学应用中的使用情况，以及热激活聚合物系统的设计。重点介绍了当前关于外部触发递送的研究，着重阐述了磁热激活系统开发中的设计与挑战。
