Petrovitch Helen, Abbott Robert D, Ross G Webster, Nelson James, Masaki Kamal H, Tanner Caroline M, Launer Lenore J, White Lon R
Pacific Health Research Institute, Honolulu, Hawaii, USA.
Mov Disord. 2009 Feb 15;24(3):371-6. doi: 10.1002/mds.22360.
Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm(2)) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial; 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with 1 or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB.
便秘与帕金森病（PD）的未来风险以及蓝斑或黑质（SN）中的路易小体（LB）有关。我们的目的是研究晚年排便频率与死后SN神经元密度之间的独立关联。在1991年至1993年的檀香山-亚洲老龄化研究中，对414名年龄在71至93岁之间且随后进行了死后评估的男性进行了排便频率评估。对大脑进行SN和蓝斑中LB的检查，并从SN的横切面的四个象限中计数神经元。在不吸烟者中，每天排便次数>1次、1次和<1次的男性，其背内侧象限的神经元密度（个/mm²）分别为18.5、18.8、10.1（P<0.001）；腹内侧象限为15.3、16.4、10.2（P<0.03）；腹外侧象限为18.6、18.3、10.9（P = 0.011）。在吸烟者中，背外侧象限或任何象限的关系均不显著。在调整了年龄、死亡时间、咖啡饮用、三头肌皮褶厚度、白天过度嗜睡、认知功能、PD和偶发性LB后，与每天排便<1次的不吸烟者相比，每天排便1次或更多次的不吸烟者的密度比显著更高。便秘与低SN神经元密度相关，且与LB的存在无关。
