Hertzog Paul
Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria, Australia.
Immunity. 2008 Nov 14;29(5):663-5. doi: 10.1016/j.immuni.2008.10.006.
Two cell response pathways, Toll-like receptor (TLR) and Notch, conserved from Drosophila to mammals are well characterized for distinct roles in innate immunity and cell development, respectively. In this issue of Immunity, Hu et al. (2008) describe and characterize the direct cooperation of these two pathways.
从果蝇到哺乳动物都保守存在的两条细胞反应通路，即Toll样受体（TLR）通路和Notch通路，分别在固有免疫和细胞发育中发挥着截然不同的作用，这已得到充分表征。在本期《免疫》杂志中，Hu等人（2008年）描述并表征了这两条通路的直接协同作用。
