Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Chicago, IL 60611, USA.
Viruses. 2013 May 23;5(5):1325-45. doi: 10.3390/v5051325.
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate these modifications, and to adaptor proteins that may recruit co-repressor complexes. Kinetic analyses of repressor binding show that these repressors are recruited at the earliest time of infection, suggesting that latency may be the default state. Kidney transplantation leads to epigenetic reprogramming of latent viral chromatin and reactivation of immediate early gene expression. Inflammatory signaling pathways, which activate transcription factors that regulate the major immediate early promoter (MIEP), likely mediate the switch in viral chromatin.
巨细胞病毒 (CMV) 的基因表达在潜伏期中受到抑制，这是由于病毒基因组的异染色质化。在潜伏感染的小鼠中，巨细胞病毒 (MCMV) 的病毒基因组与具有异染色质修饰的组蛋白、介导这些修饰的酶以及可能募集共抑制复合物的衔接蛋白结合。抑制剂结合的动力学分析表明，这些抑制剂在感染的最早时间被募集，这表明潜伏可能是默认状态。肾移植导致潜伏病毒染色质的表观遗传重编程和即刻早期基因表达的重新激活。炎症信号通路激活转录因子，调节主要即刻早期启动子 (MIEP)，可能介导病毒染色质的转换。
