[陆地棉提取物对大鼠肝损伤急性实验性肝炎的保肝作用]

[Hepatoprotective effect of Gossipium hirsutum extract on acute experimental hepatitis on rat liver injury].

作者信息

Batur M, Cheng Lu-feng, Yan Dong, Parhat K

机构信息

Department of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(15):1873-6.

PMID:19007020

Abstract

OBJECTIVE

To investigate the protective effect on the mice acute experimental hepatic injury by Flos Gossypium herbaceum extracts (FGF-I, FGF-II).

METHOD

Experimental hepatic injury model was established by a single intraperitoneal injection of 350 mg x kg(-1) D-CalN in Wistar rats. Serum samples for alanine aminotransferase (ALT), aspartate transferase (AST) level and liver homogenate samples for super oxide dismutase (SOD), malondialdehyde (MDA), Glutathione peroxidese (GSH-PX) activities were assayed.

RESULT

For acute experimental hepatic injury, FGF-I and FGF-II significantly decrease the serum transaminase activities (P < 0.01). FGF-I increased the SOD activities (P < 0.01), and decreased MDA content only for 50 mg x kg(-1) FGF-I (P < 0.05), no effect on GSH-PX activity was found for them. FGF-II increased the SOD and GSH-PX activity (P < 0.05) with decreased MDA content (P < 0.05).

CONCLUSION

FGF-I and FGF-II showed significant protective action in mice experimental hepatic injury.

摘要

目的

研究草棉花提取物（FGF-I、FGF-II）对小鼠急性实验性肝损伤的保护作用。

方法

通过向Wistar大鼠腹腔内单次注射350mg·kg⁻¹ D-氨基半乳糖建立实验性肝损伤模型。检测血清中丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）水平，以及肝匀浆中超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-PX）活性。

结果

对于急性实验性肝损伤，FGF-I和FGF-II显著降低血清转氨酶活性（P<0.01）。FGF-I增加SOD活性（P<0.01），仅50mg·kg⁻¹ FGF-I降低MDA含量（P<0.05），对GSH-PX活性无影响。FGF-II增加SOD和GSH-PX活性（P<0.05），同时降低MDA含量（P<0.05）。