Mohammed Mona A, Amer Nagat M, Abdallah Heba M I, Saleh Mai S
Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Giza, Egypt.
Environmental and Occupational Medicine Department, Environment and Climate Change Research Institute, National Research Centre, Dokki, Giza, Egypt.
Plant Methods. 2024 Apr 17;20(1):54. doi: 10.1186/s13007-024-01181-8.
Improper management of agricultural and industrial cotton wastes causes environmental pollution and worsens the climate change challenge. Green recycling of cotton could contribute to a circular economy. One of the economic values of cotton wastes lies in their bioactive components. Two types of cotton wastes-agricultural and industrial-of the species Gossypium barbadense L. Giza 95 were targeted in the current study, aiming to maximize their medicinal value and investigate the anti-inflammatory, hepatoprotective, and antioxidant activities of their phytochemical extracts. Phytochemical extraction was performed using different solvents extraction. An anti-inflammatory effect was tested in carrageenan-induced acute edema in a rat paw model. A carbon tetrachloride chronic model of liver injury was used for the assessment of hepatoprotective potential. Liver enzymes (AST and ALT), oxidative stress markers (MDA and GSH), inflammatory biomarkers (C-reactive protein), and histopathological features were investigated. As a result, ethyl acetate proved to be the solvent of best choice to extract the gossypin polyphenolics, where the extracted amount reached 14,826.2 µg/g, followed by butanol (8751.4 µg/g extract). The chloroform (CHCL) fraction showed the highest amounts of gossypol (190.7 µg/g extract), followed by petroleum ether. Cotton waste's composition analysis showed a wide range of components, including 33 metabolites such as gossypetin, polyphenolics, and other metabolites that possess therapeutic effects. Both chloroform extract and industrial waste extracts showed superior anti-inflammatory and hepatoprotective effects in comparison to other extracts. All tested extracts (ethyl acetate, chloroform, and industrial waste) showed proper antioxidant activities.
农业和工业棉花废料管理不当会造成环境污染，并加剧气候变化挑战。棉花的绿色回收利用有助于发展循环经济。棉花废料的经济价值之一在于其生物活性成分。本研究以海岛棉吉扎95的两种棉花废料——农业废料和工业废料——为研究对象，旨在最大化其药用价值，并研究其植物化学提取物的抗炎、保肝和抗氧化活性。采用不同溶剂萃取法进行植物化学萃取。在角叉菜胶诱导的大鼠足爪急性水肿模型中测试抗炎效果。采用四氯化碳慢性肝损伤模型评估保肝潜力。研究了肝酶（AST和ALT）、氧化应激标志物（MDA和GSH）、炎症生物标志物（C反应蛋白）和组织病理学特征。结果表明，乙酸乙酯被证明是提取棉皮素多酚类物质的最佳溶剂，提取量达到14826.2µg/g，其次是丁醇（8751.4µg/g提取物）。氯仿（CHCL）部分棉酚含量最高（190.7µg/g提取物），其次是石油醚。棉花废料成分分析显示其成分种类繁多，包括33种代谢物，如棉黄素、多酚类物质和其他具有治疗作用的代谢物。与其他提取物相比，氯仿提取物和工业废料提取物均显示出卓越的抗炎和保肝作用。所有测试提取物（乙酸乙酯、氯仿和工业废料）均表现出良好的抗氧化活性。
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