Boonlarppradab Chollaratt, Kauffman Christopher A, Jensen Paul R, Fenical William
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
Org Lett. 2008 Dec 18;10(24):5505-8. doi: 10.1021/ol8020644.
Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 microM for marineosin A) and selective activities in diverse cancer cell types.
从一种与链霉菌属有关的海洋沉积物放线菌培养物中分离出两种新型螺环胺类化合物，即海生菌素A和B（1, 2），它们含有两个吡咯官能团。海生菌素似乎源自类灵菌红素色素途径的未知修饰，在体外试验中对人结肠癌细胞（HCT - 116）表现出显著抑制作用（海生菌素A的IC50 = 0.5 microM），并在多种癌细胞类型中具有选择性活性。
