Shen X, Perry T L, Dunbar C D, Kelly-Borges M, Hamann M T
Department of Pharmacognosy, NCDNP, School of Pharmacy, The University of Mississippi, USA.
J Nat Prod. 1998 Oct;61(10):1302-3. doi: 10.1021/np980129a.
As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.
作为旨在鉴定用于治疗艾滋病机会性感染的先导化合物的结构导向分离的结果，从采集自伯利兹的加勒比海绵针叶艾格海绵（Agelas conifer a）中分离出一种新的对称吡咯二聚体去溴截短侧耳素（1）的二盐酸盐以及两种已知的吡咯类似物（2和3）。通过光谱数据分析确定了去溴截短侧耳素的结构。对化合物1 - 3进行了¹⁵N光谱数据归属。化合物2和3对结核分枝杆菌表现出微弱的抑制作用。
