Sintchenko Vitali
Centre for Infectious Diseases and Microbiology-Public Health, Sydney West Area Health Service, Western Clinical School, University of Sydney.
N S W Public Health Bull. 2008 Jul-Aug;19(7-8):143-5. doi: 10.1071/nb07005.
Pertussis, or whooping cough, a highly contagious disease caused by Bordetella pertussis, is making a comeback globally and nationally in spite of reasonable vaccination coverage. This paper provides an update on laboratory testing methods that assist the confirmation of clinical disease and investigation of outbreaks. Laboratory confirmation of the diagnosis by polymerase chain reaction or serology should be attempted, especially when atypical pertussis is suspected clinically. Genetic and antigenic variations in virulence factors of strains circulating in the population should also be monitored.
百日咳，又称小儿咳嗽，是一种由百日咳博德特氏菌引起的高度传染性疾病，尽管疫苗接种覆盖率合理，但它正在全球和全国范围内卷土重来。本文提供了有助于临床疾病确诊和疫情调查的实验室检测方法的最新情况。应尝试通过聚合酶链反应或血清学进行实验室诊断确认，尤其是在临床上怀疑为非典型百日咳时。还应监测人群中传播的菌株毒力因子的基因和抗原变异情况。
