Osiowy Carla, Gordon Diane, Borlang Jamie, Giles Elizabeth, Villeneuve Jean-Pierre
Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Bloodborne Pathogens and Hepatitis, National Microbiology Laboratory, Winnipeg, MB, Canada.
J Gen Virol. 2008 Dec;89(Pt 12):3009-3015. doi: 10.1099/vir.0.2008/005124-0.
Hepatitis B virus (HBV) genotype G (HBV/G) is an unusual variant, and little is known about its epidemiology and natural history, particularly the requirement for a co-infecting HBV genotype and their relationship during infection. This study investigated the quasispecies nature of co-infecting genotypes in 39 samples collected over a 6 year period from 13 HBV/G-infected patients. HBV/G infections were found to occur predominantly in males (92 %) and were primarily associated with male homosexual sex (67 %). All patients were infected with HBV/G and HBV/A, or a recombinant HBV/A/G strain. Co-infecting genotypic prevalence was often observed to fluctuate over time, with periods of HBV/G monoinfection in some patients. The average sequence divergence among Canadian HBV/G strains was 1.57+/-0.62 %. Thus, all HBV/G infections in Canada occur in the context of co-infection or recombination with HBV/A, and strains display increased sequence divergence compared with all known HBV/G sequences described to date.
乙型肝炎病毒（HBV）G基因型（HBV/G）是一种不常见的变异型，对其流行病学和自然史了解甚少，尤其是关于共感染HBV基因型的要求及其在感染过程中的关系。本研究调查了在6年期间从13例HBV/G感染患者收集的39份样本中共感染基因型的准种性质。发现HBV/G感染主要发生在男性（92%），并且主要与男性同性性行为相关（67%）。所有患者均感染了HBV/G和HBV/A，或重组HBV/A/G毒株。经常观察到共感染基因型的流行率随时间波动，一些患者出现HBV/G单一感染期。加拿大HBV/G毒株之间的平均序列差异为1.57±0.62%。因此，加拿大所有HBV/G感染均发生在与HBV/A共感染或重组的背景下，并且与迄今描述的所有已知HBV/G序列相比，毒株显示出更大的序列差异。
