Eshraghian Ahad, Hashemi Seyed Ali, Hamidian Jahromi Alireza, Eshraghian Hamed, Masoompour Seyed Masoum, Davarpanah Mohamad Ali, Eshraghian Kavus, Taghavi Seyed Alireza
Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Fars Province, Iran.
Dig Dis Sci. 2009 Sep;54(9):1966-70. doi: 10.1007/s10620-008-0557-7. Epub 2008 Nov 14.
This study aimed to determine the relation between Helicobacter pylori infection and insulin resistance in healthy subjects. In a cross-sectional case control study between January and April 2007, a total of 71 healthy subjects without the exclusion criteria completed the study. Forty-three (60.6%) patients were H. pylori positive and 28 (39.4%) patients were H. pylori negative. Age and body mass index of the patients were not significantly different between the two groups (32.2 +/- 14.2 vs. 33 +/- 8.05 years and 23.15 +/- 4.5 vs. 24.04 +/- 3.2 kg/m(2), respectively). H-pylori-positive patients had significantly higher HOMA-IR level compared to H-pylori-negative patients (3.54 +/- 2.2 vs. 2.46 +/- 1.9, respectively) (P < 0.05). Fasting serum insulin level was significantly higher in the H-pylori-positive group compared with the H-pylori-negative group (19.41 +/- 3.08 vs. 16.57 +/- 2.02 microU/ml, respectively) (P < 0.05). Our findings suggest recognition of H. pylori infection as a risk factor for insulin resistance.
本研究旨在确定健康受试者中幽门螺杆菌感染与胰岛素抵抗之间的关系。在2007年1月至4月进行的一项横断面病例对照研究中，共有71名无排除标准的健康受试者完成了研究。43名（60.6%）患者幽门螺杆菌阳性，28名（39.4%）患者幽门螺杆菌阴性。两组患者的年龄和体重指数无显著差异（分别为32.2±14.2岁对33±8.05岁，以及23.15±4.5对24.04±3.2 kg/m²）。与幽门螺杆菌阴性患者相比，幽门螺杆菌阳性患者的HOMA-IR水平显著更高（分别为3.54±2.2对2.46±1.9）（P<0.05）。幽门螺杆菌阳性组的空腹血清胰岛素水平显著高于幽门螺杆菌阴性组（分别为19.41±3.08对16.57±2.02 μU/ml）（P<0.05）。我们的研究结果表明，幽门螺杆菌感染可被视为胰岛素抵抗的一个危险因素。
