Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
BMC Gastroenterol. 2020 Mar 24;20(1):77. doi: 10.1186/s12876-020-01223-0.
There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus.
A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990-March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case-control studies were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis.
A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR = 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population, CONCLUSION: In overall a positive association between H. pylori infection and diabetes mellitus was found.
有几项研究结果各不相同且混杂，探讨了幽门螺杆菌（H. pylori）与糖尿病之间可能存在的关系。因此，本项荟萃分析旨在确定 H. pylori 感染与糖尿病风险之间的关联。
系统检索国际数据库，包括 Medline（PubMed）、Web of Sciences、Scopus、EMBASE 和 CINHAL（1990 年 1 月至 2019 年 3 月），以鉴定研究 H. pylori 感染与糖尿病之间关系的病例对照研究。仅对病例对照研究采用比值比（OR）和 95%置信区间（CI）进行分析。进行分层和亚组分析以探讨研究之间的异质性并评估研究质量的影响。还对数和标准误差对数比值比（OR）进行了荟萃分析。
共分析了 41 项研究，涉及 9559 人（病例组 4327 人，对照组 5232 人）。H. pylori 感染与糖尿病之间关联的汇总估计值为 OR=1.27（95%CI 1.11-1.45，P=0.0001，I=86.6%）。H. pylori 感染对糖尿病（包括两种类型）、1 型和 2 型糖尿病的影响分别为 1.17（95%CI 0.94-1.45）、1.19（95%CI 0.98-1.45）和 1.43（95%CI 1.11-1.85）。按地理位置进行的亚组分析显示，亚洲人群中 H. pylori 感染对糖尿病的影响风险略高于其他人群。
总体而言，发现 H. pylori 感染与糖尿病之间存在正相关关系。
