Fujimiya Mineko, Asakawa Akihiro, Ataka Koji, Kato Ikuo, Inui Akio
Department of Anatomy, Sapporo Medical University, School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
World J Gastroenterol. 2008 Nov 7;14(41):6318-26. doi: 10.3748/wjg.14.6318.
Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin.
三种肽，即胃饥饿素、去酰基胃饥饿素和肥胖抑制素，是由一种共同的前激素——前胃饥饿素原经翻译后加工产生的，它们源自胃中的内分泌细胞。为了研究这些肽的作用，我们在自由活动的清醒大鼠模型中应用了胃肠动力的压力测量法。胃饥饿素在动物的进食和禁食状态下均对胃窦和十二指肠的动力产生刺激作用。去酰基胃饥饿素在动物禁食状态下对胃窦动力产生抑制作用，但对十二指肠动力无抑制作用。肥胖抑制素在动物进食状态下对胃窦和十二指肠动力产生抑制作用，但在禁食状态下无此作用。大脑中的神经肽Y Y2或Y4受体可能介导胃饥饿素的作用，大脑中的促肾上腺皮质激素释放因子2型受体介导去酰基胃饥饿素的作用，而大脑中的促肾上腺皮质激素释放因子1型和2型受体介导肥胖抑制素的作用。迷走神经传入通路可能参与胃饥饿素的作用，但不参与去酰基胃饥饿素的作用，而迷走神经传入通路可能部分参与肥胖抑制素的作用。
