Caignard A, Martin M, Reisser D, Thomas B, Martin F
Br J Cancer. 1984 Nov;50(5):661-5. doi: 10.1038/bjc.1984.233.
The effects of cimetidine and indomethacin on the growth of dimethylhydrazine induced or transplanted intestinal tumours in the rat have been studied. Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis. Two models of rat intestinal tumours were used: a colon carcinoma line transplantable in syngeneic animals and intestinal tumours induced by dimethylhydrazine treatment of Sprague-Dawley rats. Cimetidine and indomethacin were given in drinking water, alone or in combination. Cimetidine had no effect on the growth of transplanted colon cancer but significantly increased the incidence of chemically-induced tumours, with a tendency toward more invasive and metastatic tumours than in the control animals. Indomethacin did not significantly modify the incidence or other characteristics of the tumours in any of the models. This result is at variance with a protective effect of indomethacin on chemically-induced rat colon cancer previously reported by others.
已研究了西咪替丁和吲哚美辛对二甲基肼诱导或移植的大鼠肠道肿瘤生长的影响。西咪替丁是一种组胺2型受体拮抗剂，吲哚美辛是一种前列腺素合成抑制剂。使用了两种大鼠肠道肿瘤模型：一种可在同基因动物中移植的结肠癌细胞系，以及通过对斯普拉格-道利大鼠进行二甲基肼处理诱导的肠道肿瘤。西咪替丁和吲哚美辛单独或联合添加到饮用水中给予。西咪替丁对移植的结肠癌生长没有影响，但显著增加了化学诱导肿瘤的发生率，与对照动物相比，有产生更具侵袭性和转移性肿瘤的趋势。在任何模型中，吲哚美辛均未显著改变肿瘤的发生率或其他特征。这一结果与其他人先前报道的吲哚美辛对化学诱导的大鼠结肠癌的保护作用不一致。
