Liguori Giovanni, Trombetta Carlo, Bucci Stefano, Benvenuto Sara, Amodeo Antonio, Ocello Giuseppe, Belgrano Emanuele
Department of Urology, University of Trieste, Italy.
Arch Ital Urol Androl. 2008 Sep;80(3):99-102.
We evaluated the impact of removal of the tumour bearing testis on semen quality in men with testicular cancer and the effect of tumour histologic feature on semen quality.
We took into account the semen analysis before and after orchiectomy in 30 patients.
The median sperm concentration before and after orchiectomy was respectively of 26.7 x 10(6)/ml (range: 0-120 x 10(6)/ml) and 16.6 x 10(6)/ml (range: 0-75 x 10(6)/ml) (p = 0.001). Median sperm concentration before and after surgery in patients affected by seminomatous cancer were respectively of 35.47 x 10(6)/ml and 23.99 x 10(6)/ml, while cases of non-seminomatous cancer were respectively of 17.9 x 10(6)/ml and 8.16 x 10(6)/ml.
Semen quality at the diagnosis was poorer in patients affected by non-seminomatous testicular cancer. Sperm concentration deteriorated after orchiectomy. Our findings suggest that the most appropriate time for cryopreservation of semen is before orchiectomy.
我们评估了切除患肿瘤的睾丸对睾丸癌男性精液质量的影响以及肿瘤组织学特征对精液质量的影响。
我们纳入了30例患者睾丸切除术前和术后的精液分析情况。
睾丸切除术前和术后的精子浓度中位数分别为26.7×10⁶/ml（范围：0 - 120×10⁶/ml）和16.6×10⁶/ml（范围：0 - 75×10⁶/ml）（p = 0.001）。精原细胞瘤患者手术前后的精子浓度中位数分别为35.47×10⁶/ml和23.99×10⁶/ml，而非精原细胞瘤患者分别为17.9×10⁶/ml和8.16×10⁶/ml。
非精原细胞瘤性睾丸癌患者诊断时的精液质量较差。睾丸切除术后精子浓度下降。我们的研究结果表明，精液冷冻保存的最合适时间是在睾丸切除术前。
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