多菌型麻风患者在接受多药联合治疗后的复发情况。
Relapses in multibacillary leprosy patients after multidrug therapy.
作者信息
Poojabylaiah Mitranna, Marne Ramesh Bhat, Varikkodan Rajina, Bala Nandakishore, Dandakeri Sukumar, Martis Jacintha
机构信息
Father Muller Medical College Hospital, Kankanady, Mangalore 575 002, Karnataka, India.
出版信息
Lepr Rev. 2008 Sep;79(3):320-4.
OBJECTIVES
To determine the magnitude of relapses in multibacillary leprosy patients after multi-drug therapy and to determine the factors influencing the relapse.
DESIGN
A retrospective study pertaining to multibacillary leprosy patients treated with MBMDT as per WHO guidelines was carried out. The study included 300 MB patients who had successfully completed treatment during 1986-2002, of whom 163 patients were available for follow-up. Patients were examined clinically and bacteriologically to asses the present status of disease.
RESULTS
A total of three cases relapsed at 2, 4 and 11 years after being released from treatment which gives a crude cumulative relapse rate of 1.84% for the 18 year period of follow-up with mean duration of follow-up 7.13 +/- 1.25 years. It also gives the total follow-up period of 1163 person-years with the relapse rate of 0.26/100 person-years of follow-up (95% confidence interval is 0.235-0.285).
CONCLUSION
Relapse rate after WHO recommended MDT leprosy is low. High bacterial load before initiation of therapy is an important factor which determines the relapse.
目的
确定多菌型麻风患者接受多药联合治疗后的复发率，并确定影响复发的因素。
设计
开展一项回顾性研究，研究对象为按照世界卫生组织指南接受多菌型麻风联合化疗（MBMDT）治疗的多菌型麻风患者。该研究纳入了300例在1986年至2002年期间成功完成治疗的多菌型患者，其中163例患者可供随访。对患者进行临床和细菌学检查，以评估疾病现状。
结果
共有3例患者在停止治疗后2年、4年和11年复发，在18年的随访期内，粗略累积复发率为1.84%，平均随访时间为7.13±1.25年。总随访人年数为1163人年，复发率为0.26/100人年随访（95%置信区间为0.235 - 0.285）。
结论
世界卫生组织推荐的麻风多药联合治疗后的复发率较低。治疗开始前细菌载量高是决定复发的一个重要因素。
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