Poojabylaiah Mitranna, Marne Ramesh Bhat, Varikkodan Rajina, Bala Nandakishore, Dandakeri Sukumar, Martis Jacintha
Father Muller Medical College Hospital, Kankanady, Mangalore 575 002, Karnataka, India.
Lepr Rev. 2008 Sep;79(3):320-4.
To determine the magnitude of relapses in multibacillary leprosy patients after multi-drug therapy and to determine the factors influencing the relapse.
A retrospective study pertaining to multibacillary leprosy patients treated with MBMDT as per WHO guidelines was carried out. The study included 300 MB patients who had successfully completed treatment during 1986-2002, of whom 163 patients were available for follow-up. Patients were examined clinically and bacteriologically to asses the present status of disease.
A total of three cases relapsed at 2, 4 and 11 years after being released from treatment which gives a crude cumulative relapse rate of 1.84% for the 18 year period of follow-up with mean duration of follow-up 7.13 +/- 1.25 years. It also gives the total follow-up period of 1163 person-years with the relapse rate of 0.26/100 person-years of follow-up (95% confidence interval is 0.235-0.285).
Relapse rate after WHO recommended MDT leprosy is low. High bacterial load before initiation of therapy is an important factor which determines the relapse.
确定多菌型麻风患者接受多药联合治疗后的复发率，并确定影响复发的因素。
开展一项回顾性研究，研究对象为按照世界卫生组织指南接受多菌型麻风联合化疗（MBMDT）治疗的多菌型麻风患者。该研究纳入了300例在1986年至2002年期间成功完成治疗的多菌型患者，其中163例患者可供随访。对患者进行临床和细菌学检查，以评估疾病现状。
共有3例患者在停止治疗后2年、4年和11年复发，在18年的随访期内，粗略累积复发率为1.84%，平均随访时间为7.13±1.25年。总随访人年数为1163人年，复发率为0.26/100人年随访（95%置信区间为0.235 - 0.285）。
世界卫生组织推荐的麻风多药联合治疗后的复发率较低。治疗开始前细菌载量高是决定复发的一个重要因素。
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