Li H Y, Hu L F, Huang W B, Liu G C, Yuan L C, Jin Z, Li X, Li J L, Yang Z M
Beijing Tropical Medical Research Institute, China.
Int J Lepr Other Mycobact Dis. 1997 Jun;65(2):238-45.
Between 1986 and 1995, 8307 leprosy patients have completed fixed-duration multidrug therapy (FD-MDT) and were followed annually for possible relapse. The mean relapse rate for multibacillary (MB) leprosy is 0.15/1000 person-years (py) and for paucibacillary (PB) 0.55/1000 py. There is no difference in the relapse rates between patients with or without chemotherapy before FD-MDT. In MB patients, the five relapses occurred between 4 and 7 years; in PB patients, five relapses occurred at 4-5 years after FD-MDT. Six additional PB relapses self-reported 1-4 years after the 5-year surveillance period and were not included in the relapse rates. Most PB patients relapsed into MB due to wrong classification and insufficient therapy. For the known 62 irregular MB patients the cumulative relapse rate is 6.5%.
1986年至1995年间，8307例麻风病患者完成了固定疗程的多药联合化疗（FD-MDT），并每年进行随访以观察是否可能复发。多菌型（MB）麻风病的平均复发率为0.15/1000人年（py），少菌型（PB）为0.55/1000 py。在接受FD-MDT之前接受或未接受化疗的患者之间，复发率没有差异。在MB患者中，5例复发发生在4至7年之间；在PB患者中，5例复发发生在FD-MDT后的4至5年。在5年监测期后的1至4年，又有6例PB复发是患者自行报告的，未纳入复发率计算。大多数PB患者因分类错误和治疗不足而复发为MB。对于已知的62例不规则MB患者，累积复发率为6.5%。
