麻风病治疗的当前方法与未来方向。
Current approaches and future directions in the treatment of leprosy.
作者信息
Worobec Sophie M
机构信息
Department of Dermatology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA,
出版信息
Res Rep Trop Med. 2012 Aug 1;3:79-91. doi: 10.2147/RRTM.S27395. eCollection 2012.
Abstract
This review surveys current treatments and future treatment trends in leprosy from a clinical perspective. The World Health Organization provides a multidrug treatment regimen that targets the bacillus which causes leprosy. Several investigational drugs are available for the treatment of drug-resistant . Future directions in leprosy treatment will focus on: the molecular signaling mechanism uses to avoid triggering an immune response; prospective studies of the side effects experienced during multiple-drug therapy; recognition of relapse rates post-completion of designated treatments; combating multidrug resistance; vaccine development; development of new diagnostic tests; and the implications of the recent discovery of a genetically distinct leprosy-causing bacillus, .
摘要
本综述从临床角度审视了麻风病的当前治疗方法和未来治疗趋势。世界卫生组织提供了一种针对引起麻风病的杆菌的多药治疗方案。有几种研究性药物可用于治疗耐药性麻风病。麻风病治疗的未来方向将集中在：用于避免触发免疫反应的分子信号传导机制；多药治疗期间所经历副作用的前瞻性研究；指定治疗完成后复发率的识别；对抗多药耐药性；疫苗开发；新诊断测试的开发；以及最近发现一种基因上不同的麻风病致病杆菌的影响。
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