Mattia Donatella, Cincotti Febo, Astolfi Laura, de Vico Fallani Fabrizio, Scivoletto Giorgio, Marciani Maria Grazia, Babiloni Fabio
Neurofisiopatologia Clinica, Fondazione Santa Lucia, IRCCS, Via Ardeatina, 306, 00179 Rome, Italy.
Clin Neurophysiol. 2009 Jan;120(1):181-9. doi: 10.1016/j.clinph.2008.09.023. Epub 2008 Nov 14.
The maintenance of a motor cortical program in the temporal domain is relevant to current neuroinformatic efforts to use non-invasive EEG signals to control neuroprosthetic devices designed to restore natural movements of paralyzed body parts. Here we use an advance neuroelectrical imaging approach to examine the motor cortical responsiveness in human tetraplegia.
High resolution-electroencephalographic (EEG) recordings were performed in five subjects with tetraplegia due to chronic, complete spinal cord injuries (SCIs) while they attempted self-generated movements of a plegic body part (foot), and in five healthy subjects executing simple foot movements.
Self-generated movement attempts induced significant EEG sources of activity in a set of motor-related areas (including the primary motor area, MI) similar to what observed during the preparatory stages of movement execution (control subjects). Functional connectivity showed a preferential interaction between the "non-primary" motor areas and the putative MI foot site, as estimated for both motor execution and attempt. Under this latter condition however, it could be observed an "enlargement" of the functional network by including the left superior parietal cortex.
Our findings indicate the existence of a functional circuit subserving the attempted motion in SCI subjects that encompasses a set of areas known to play a role in motor execution, yet reveals differences in the functional interaction between these areas.
The understanding of changes in the motor circuitry is relevant to current neuroinformatic efforts to use non-invasive EEG signals to control neuroprosthetic devices designed to benefit paralyzed persons.
在时间域维持运动皮层程序与当前利用非侵入性脑电图信号控制旨在恢复瘫痪身体部位自然运动的神经假体装置的神经信息学研究相关。在此，我们采用先进的神经电成像方法来研究人类四肢瘫痪患者的运动皮层反应性。
对5例因慢性完全性脊髓损伤（SCI）导致四肢瘫痪的患者在试图自主运动瘫痪身体部位（足部）时进行高分辨率脑电图（EEG）记录，同时对5名执行简单足部运动的健康受试者进行记录。
自主运动尝试在一组与运动相关的区域（包括初级运动区，MI）诱发了显著的EEG活动源，类似于在运动执行准备阶段（对照受试者）观察到的情况。功能连接显示，在运动执行和尝试过程中，“非初级”运动区与假定的MI足部区域之间存在优先相互作用。然而，在后一种情况下，可以观察到通过纳入左侧顶上叶皮层，功能网络出现“扩大”。
我们的研究结果表明，在SCI患者中存在一个支持尝试性运动的功能回路，该回路包含一组已知在运动执行中起作用的区域，但揭示了这些区域之间功能相互作用的差异。
理解运动神经回路的变化与当前利用非侵入性EEG信号控制旨在使瘫痪患者受益的神经假体装置的神经信息学研究相关。
