血液透析患者的丁酰胆碱酯酶活性与死亡风险：与超敏C反应蛋白和白蛋白的比较

Butyrylcholinesterase activity and mortality risk in hemodialysis patients: comparison to hsCRP and albumin.

作者信息

Stojanov Marina D, Jovicić Dusanka M, Djurić Stevan P, Konjević Marija M, Todorović Zoran M, Prostran Milica S

机构信息

Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, PO Box 146, 11000 Belgrade, Serbia.

出版信息

Clin Biochem. 2009 Jan;42(1-2):22-6. doi: 10.1016/j.clinbiochem.2008.10.010. Epub 2008 Nov 5.

DOI:10.1016/j.clinbiochem.2008.10.010

PMID:19010318

Abstract

OBJECTIVE

To test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin.

MATERIALS AND METHODS

The study enrolled 62 patients, aged 31-79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albumin were measured after 1, 3, 9 and 12 months of dialysis. The Kaplan-Meier survival curves were employed in mortality prediction.

RESULTS

BuChE was positively associated with serum albumin (r=0.318; p=0.012) and inversely related to hsCRP (r=-0.358; p=0.004). The highest mortality was in the lowest quartile of basal albumin (<38.4 g/L; p=0.027), hsCRP concentrations >8 mg/L (p=0.005), and BuChE activity in the lowest tercile of basal values (<5.92 kU/L; p=0.0041).

CONCLUSION

Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in patients who are on hemodialysis.

摘要

目的

检测丁酰胆碱酯酶（BuChE）活性对血液透析患者12个月随访期间死亡风险的预测能力，并与超敏C反应蛋白（hsCRP）和白蛋白进行比较。

材料与方法

本研究纳入了62例年龄在31 - 79岁之间的患者。在透析1、3、9和12个月后测量血清BuChE、高敏C反应蛋白（hsCRP）和白蛋白。采用Kaplan - Meier生存曲线进行死亡预测。

结果

BuChE与血清白蛋白呈正相关（r = 0.318；p = 0.012），与hsCRP呈负相关（r = - 0.358；p = 0.004）。基础白蛋白最低四分位数（<38.4 g/L；p = 0.027）、hsCRP浓度>8 mg/L（p = 0.005）以及基础值最低三分位数的BuChE活性（<5.92 kU/L；p = 0.0041）时死亡率最高。