Temel A, Kazokoglu H, Taga Y, Orkan A L
Department of Ophthalmology, University of Marmara, Istanbul, Turkey.
CLAO J. 1991 Jan;17(1):69-71.
We assayed tear immunoglobulins (IgA, IgG, and IgM) by radial immunodiffusion in 24 contact lens wearers and 22 healthy control subjects. IgA level was found to be increased (P less than or equal to 0.02) in rigid contact lens wearers (mean: 0.14 +/- 0.07 g/L) compared to control subjects (mean: 0008 +/- 0.06 g/L). IgA levels of both of PMMA contact lens wearers (mean: 0.14 +/- 0.08 g/L; P less than or equal to 0.05) and rigid gas permeable contact lens wearers (mean: 0.13 +/- 0.07 g/L; P less than or equal to 0.05) were increased in comparison with the control group. No statistically significant differences were found in IgA levels of various types of soft contact lens wearers or in IgG or IgM levels between wearers and controls. The mean duration of lens wear was 6.4 years (range: 1-20 years), and an increase in IgG level was found, related length of lens wear (P less than or equal to 0.03). We believe that the continuous mechanical stimulation of conjunctiva alters the level of tear immunoglobulins, especially the IgA type.
我们采用放射免疫扩散法对24名隐形眼镜佩戴者和22名健康对照者的泪液免疫球蛋白（IgA、IgG和IgM）进行了检测。结果发现，与对照者（平均值：0.008±0.06g/L）相比，硬性隐形眼镜佩戴者（平均值：0.14±0.07g/L）的IgA水平升高（P≤0.02）。与对照组相比，PMMA隐形眼镜佩戴者（平均值：0.14±0.08g/L；P≤0.05）和硬性透气性隐形眼镜佩戴者（平均值：0.13±0.07g/L；P≤0.05）的IgA水平均升高。在不同类型软性隐形眼镜佩戴者的IgA水平或佩戴者与对照者之间的IgG或IgM水平上未发现统计学显著差异。隐形眼镜佩戴的平均时长为6.4年（范围：1 - 20年），并且发现IgG水平升高与隐形眼镜佩戴时长相关（P≤0.03）。我们认为结膜的持续机械刺激会改变泪液免疫球蛋白的水平，尤其是IgA类型。
