Edwards Kate M, Mills Paul J
School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Maturitas. 2008 Dec 20;61(4):330-3. doi: 10.1016/j.maturitas.2008.09.024. Epub 2008 Nov 17.
The purpose of this study was to compare the effects of 3 months of estrogen replacement therapy, estrogen plus progesterone replacement therapy and a placebo, on the resting cortisol and interleukin-6 (IL-6) levels in post-menopausal women.
Forty-three women were randomised to one of three treatment arms: estradiol 2mg/day (ERT), estradiol 2mg/day plus medroxyprogesterone acetate 5mg/day (HRT), or a placebo that was administered orally for 3 months.
Cortisol levels showed a significant condition by intervention interaction. Post hoc tests showed that ERT significantly increased cortisol levels after treatment compared to baseline, while in the HRT group a trend toward increased cortisol was found. No changes were observed in IL-6 levels.
Estrogen administration elevated cortisol levels, but this effect may be moderated by progestins. IL-6 was not altered by ERT or HRT, future studies should consider the interaction of cortisol increases on change in IL-6 expression.
本研究旨在比较3个月的雌激素替代疗法、雌激素加孕激素替代疗法和安慰剂对绝经后女性静息皮质醇和白细胞介素-6（IL-6）水平的影响。
43名女性被随机分为三个治疗组之一：每天服用2mg雌二醇（ERT）、每天服用2mg雌二醇加5mg醋酸甲羟孕酮（HRT）或口服安慰剂3个月。
皮质醇水平显示出干预与条件之间的显著交互作用。事后检验表明，与基线相比，ERT治疗后皮质醇水平显著升高，而在HRT组中发现皮质醇有升高趋势。IL-6水平未观察到变化。
给予雌激素可提高皮质醇水平，但孕激素可能会缓和这种作用。ERT或HRT未改变IL-6水平，未来研究应考虑皮质醇升高对IL-6表达变化的相互作用。
