Branco Monica C, Schneider Joel P
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Acta Biomater. 2009 Mar;5(3):817-31. doi: 10.1016/j.actbio.2008.09.018. Epub 2008 Oct 10.
A growing number of medications must be administered through parenteral delivery, i.e., intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the therapeutic. For some therapeutics, the use of delivery vehicles in conjunction with this delivery mechanism can improve drug efficacy and patient compliance. Macromolecular self-assembly has been exploited recently to engineer materials for the encapsulation and controlled delivery of therapeutics. Self-assembled materials offer the advantages of conventional crosslinked materials normally used for release, but also provide the ability to tailor specific bulk material properties, such as release profiles, at the molecular level via monomer design. As a result, the design of materials from the "bottom up" approach has generated a variety of supramolecular devices for biomedical applications. This review provides an overview of self-assembling molecules, their resultant structures, and their use in therapeutic delivery. It highlights the current progress in the design of polymer- and peptide-based self-assembled materials.
越来越多的药物必须通过肠胃外给药方式，即静脉注射、肌肉注射或皮下注射来给药，以确保治疗效果。对于某些治疗药物，将给药载体与这种给药机制结合使用可以提高药物疗效和患者的依从性。最近，大分子自组装已被用于设计用于治疗药物封装和控释的材料。自组装材料具有通常用于释放的传统交联材料的优点，还能够通过单体设计在分子水平上定制特定的块状材料特性，如释放曲线。因此，从“自下而上”的方法设计材料已经产生了各种用于生物医学应用的超分子装置。本文综述了自组装分子、其形成的结构及其在治疗给药中的应用。它突出了基于聚合物和肽的自组装材料设计方面的当前进展。
