Thermo-Responsive Polymer-Based Nanoparticles: From Chemical Design to Advanced Applications.

Thermo-responsive polymers have emerged as a cutting-edge tool in nanomedicine, paving the way for innovative approaches to targeted drug delivery and advanced therapeutic strategies. These "smart" polymers respond to temperature changes, enabling controlled drug release in pathological environments characterized by high temperatures. By exploiting their unique phase transition, occurring at the lower or upper critical solution temperatures (LCST and UCST), these systems ensure localized therapeutic action, minimizing collateral damage to healthy tissues. The integration of these polymers into nanoparticles with hydrophilic shells and hydrophobic cores enhances their stability and biocompatibility. Furthermore, advanced polymer engineering allows precise modulation of LCST and UCST through adjustments in composition and hydrophilic-lipophilic balance, optimizing their responsiveness for specific applications. In addition to drug delivery, thermo-responsive nanoparticles are gaining attention in several fields such as gene therapy and imaging. Therefore, this review explores the chemical and structural diversity of thermo-responsive nanoparticles, emphasizing their ability to encapsulate and release drugs effectively. Second, this review highlights the potential of thermo-responsive nanoparticles to redefine treatment paradigms, providing a comprehensive understanding of their mechanisms, applications, and future perspectives in biomedical research.