Est-Witte Savannah, Jain Manav, Ben-Akiva Elana, Yang Joanna, Warren Tiarra, Tzeng Stephany Y, Green Jordan J
Department of Biomedical Engineering, Institute for NanoBioTechnology, Translational Tissue Engineering Center, and the Johns Hopkins Translational Immunoengineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Departments of Ophthalmology, Oncology, Neurosurgery, Materials Science & Engineering, and Chemical & Biomolecular Engineering, and the Bloomberg≈Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Adv Healthc Mater. 2025 Jun 29:e2501400. doi: 10.1002/adhm.202501400.
The immune system plays a critical role in the efficacy of regenerative medicine biotechnology, often mediated by delivery biomaterials. In this review, materials design approaches and challenges for the delivery of biomaterial platforms to endogenous cells and tissues to control their function are discussed. These delivery biomaterials can recruit and direct the phenotypes of cells including macrophages, T cells, and mesenchymal stem cells. Key considerations regarding the relevant cell types for tissue engineering and how biomaterials can be used to engineer the optimal immune microenvironment for tissue regeneration are described. The major classes of biomaterial delivery strategies utilized for immunomodulation in the context of tissue repair -scaffold-, cell-, and particle-mediated delivery- are reviewed along with how to utilize them to aid in tissue regeneration.
免疫系统在再生医学生物技术的功效中起着关键作用，这一过程通常由递送生物材料介导。在本综述中，讨论了将生物材料平台递送至内源性细胞和组织以控制其功能的材料设计方法和挑战。这些递送生物材料可以招募并引导包括巨噬细胞、T细胞和间充质干细胞在内的细胞表型。描述了关于组织工程相关细胞类型的关键考虑因素，以及生物材料如何用于构建组织再生的最佳免疫微环境。综述了在组织修复背景下用于免疫调节的主要生物材料递送策略——支架介导、细胞介导和颗粒介导的递送——以及如何利用它们来促进组织再生。
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