Kawai Masanobu, Rosen Clifford J
Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074-7205, USA.
Pediatr Nephrol. 2009 Jul;24(7):1277-85. doi: 10.1007/s00467-008-1040-6. Epub 2008 Nov 15.
Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu.
对人类和动物的研究表明，胰岛素样生长因子（IGF）-I与骨骼生长之间存在密切关联。然而，这种作用背后确切的分子和细胞机制在很大程度上仍不清楚。用于体内研究的分子和遗传技术的最新进展为我们探索循环和骨骼中的胰岛素样生长因子-I（IGF-I）如何不仅影响骨峰值，还影响骨质流失提供了出色的工具。本综述重点介绍了最近的研究发现，这些发现为IGF-I信号通路与其他骨骼网络的相互作用以及IGF-I在骨髓微环境中的作用提供了新的线索。
