Araya A Veronica, Orellana Ximena, Espinoza Jaime
Endocrinology Section, Department of Internal Medicine, University of Chile Clinical Hospital, Santos Dumont 999, Independencia, Santiago, Chile.
Endocrine. 2008 Jun;33(3):300-4. doi: 10.1007/s12020-008-9090-x.
Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity.
To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects.
Seventeen healthy overweight and obese subjects of both sexes (24 - 48 years, BMI 34.6 +/- 1.1 kg/m2).
Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed.
There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 +/- 0.87 to 6.75 +/- 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = -0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04).
Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.
脑源性神经营养因子（BDNF）已成为与胰岛素抵抗和肥胖相关的一个新因素。
评估为期3个月的低热量饮食（RCD）对超重和肥胖受试者血清BDNF浓度的影响。
17名健康的超重和肥胖受试者，男女皆有（年龄24 - 48岁，BMI 34.6 +/- 1.1 kg/m²）。
在基线和第三个月末测量人体测量学指标、口服葡萄糖耐量试验（OGTT）、血脂水平和血清BDNF。低热量饮食定义为能量摄入减少25%，其组成为：55%碳水化合物、20%蛋白质和25%脂肪（饱和脂肪少于10%，非饱和脂肪超过10%）。不允许食用精制糖。
经过3个月的RCD后，BMI、腰围、体脂百分比、空腹血糖、OGTT后血糖水平、血糖曲线下面积和HOMA2-IR均显著降低。血清BDNF显著升高（从3.97 +/- 0.87 ng/ml升至6.75 +/- 1.62 ng/ml，P = 0.02）。最终血清BDNF与体重呈负相关（r = -0.51，P = 0.03），基础OGTT后胰岛素与最终血清BDNF呈正相关（r = 0.48，P = 0.04）。
在进行3个月的RCD后，胰岛素抵抗的超重和肥胖受试者血清BDNF升高。这一观察结果可能表明，BDNF在人类体内可能通过饮食组成受到调节。
