Shah Shetal I, Turcotte Frances, Meng Hong Dao
Department of Pediatrics, Division of Neonatology, State University of New York at Stony Brook, School of Medicine, Stony Brook, NY 11791, USA.
J Matern Fetal Neonatal Med. 2008 Oct;21(10):752-7. doi: 10.1080/14767050802251156.
To ascertain the rate of influenza immunization in pregnant couples whose infants required neonatal intensive care unit (NICU) admission, and to clarify predictors for trivalent inactivated influenza vaccine (TIV) use in this targeted parent population.
During the 2005-07 influenza seasons, parents of NICU patients at two level III centers were surveyed about TIV after their infant's NICU admission. Data on immunization history, location of immunization, and other risk factors for influenza were assessed. Infant data including birth weight, gestational age, and multiple births were also obtained.
Seven hundred and eighty-six parents had infants in the NICU. Five hundred and forty-seven (69.5%) were surveyed. The overall parental rate of vaccination was 23.2% (127/547). The parental vaccination rate did not differ between years (23.2% vs. 23.2%). Mothers were less likely to have received TIV prior to delivery than fathers (17.0% vs. 28.4%; p < 0.02). Of the population, 19.3% received immunization from their OB/GYN. A concordance rate of 8.9% was noted between married couples receiving TIV. More parents received TIV in January and February of the influenza seasons than November and December (p < 0.05, Student's t-test). Influenza immunization rate in NICU parents was unrelated to infant's gestational age, parental age, total number of risk factors for TIV, hospital length of stay, multiple gestation, or need for high risk obstetrical care.
TIV rates among high-risk pregnant parents whose infants are admitted to NICU are lower than expected compared with the general population. Patient refusal of influenza vaccine is not a major obstacle toward acceptance.
确定其婴儿需要入住新生儿重症监护病房(NICU)的孕妇夫妇的流感疫苗接种率,并明确该目标父母群体使用三价灭活流感疫苗(TIV)的预测因素。
在2005 - 2007年流感季节期间,对两家三级医疗中心NICU患者的父母在其婴儿入住NICU后进行了关于TIV的调查。评估了免疫史、免疫接种地点以及其他流感危险因素的数据。还获取了婴儿数据,包括出生体重、胎龄和多胎情况。
786名父母的婴儿入住了NICU。对其中547名(69.5%)进行了调查。父母的总体疫苗接种率为23.2%(127/547)。各年份之间父母的疫苗接种率无差异(23.2%对23.2%)。母亲在分娩前接受TIV的可能性低于父亲(17.0%对28.4%;p < 0.02)。在该人群中,19.3%从妇产科医生处接受了免疫接种。接受TIV的已婚夫妇之间的一致率为8.9%。与11月和12月相比,更多父母在流感季节的1月和2月接受了TIV(p < 0.05,学生t检验)。NICU父母的流感疫苗接种率与婴儿的胎龄、父母年龄、TIV的危险因素总数、住院时间、多胎妊娠或高危产科护理需求无关。
与一般人群相比,其婴儿入住NICU的高危孕妇父母的TIV接种率低于预期。患者拒绝接种流感疫苗并非接受疫苗的主要障碍。