Silverman J F, Zhu B, Liu Y, Lin X
Department of Pathology, Allegheny General Hospital, Pittsburgh, USA.
Histol Histopathol. 2009 Jan;24(1):77-82. doi: 10.14670/HH-24.77.
Mucinous cystic neoplasms (MCNs) of the pancreas, ovary and lung have a similar histologic appearance. We investigated if immunohistochemical (IHC) studies could help in separating these neoplasms. Twenty-six ovarian MCNs (invasive carcinoma and borderline tumor), 12 pancreatic MCNs (invasive carcinoma, and with moderate or high-grade dysplasia), and 3 pulmonary MCNs (only invasive carcinoma) were retrieved. Our study demonstrated that pancreatic MCNs are positive for CDX-2 (67%), PDX-1 (100%), CK7 (83%) and CK20 (100%), while are negative for CA-125. The IHC profile of ovarian intestinal type MCN is similar to that of pancreatic MCNs, except for lower frequency of CDX-2 expression (29% vs. 67%). Ovarian endocervical like MCNs are positive for CA-125 (100%) and CK7 (100%), while are negative for CDX-2, PDX-1 and CK20. Pulmonary MCNs are positive for CDX-2 (100%), CK7 (100%) and CK20 (100%), while are negative for PDX-1 and CA-125. All tumors are negative for TTF-1, D2-40 and WT-1. We concluded that an IHC panel of CDX-2, PDX-1, CA-125, and CK20 is useful in separating MCNs of the pancreas, ovary and lung.
胰腺、卵巢和肺的黏液性囊性肿瘤（MCNs）具有相似的组织学表现。我们研究了免疫组织化学（IHC）研究是否有助于区分这些肿瘤。检索到26例卵巢MCNs（浸润性癌和交界性肿瘤）、12例胰腺MCNs（浸润性癌，伴中度或高级别发育异常）和3例肺MCNs（仅浸润性癌）。我们的研究表明，胰腺MCNs对CDX-2（67%）、PDX-1（100%）、CK7（83%）和CK20（100%）呈阳性，而对CA-125呈阴性。卵巢肠型MCNs的IHC特征与胰腺MCNs相似，除了CDX-2表达频率较低（29%对67%）。卵巢宫颈内膜样MCNs对CA-125（100%）和CK7（100%）呈阳性，而对CDX-2、PDX-1和CK20呈阴性。肺MCNs对CDX-2（100%）、CK7（100%）和CK20（100%）呈阳性，而对PDX-1和CA-125呈阴性。所有肿瘤对TTF-1、D2-40和WT-1均为阴性。我们得出结论，CDX-2、PDX-1、CA-125和CK20的IHC组合有助于区分胰腺、卵巢和肺的MCNs。
