Hase Eliane Azeka, Shinohara Henrique Norio, Alves Filho João Alberto Garcia, Sadalla José Carlos, Ab Saber Alexandre Muxfeldt, Francisco Rossana Pulcineli Vieira
Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo Medical School, São Paulo, Brazil.
Graduate Program, University of São Paulo Medical School, São Paulo, Brazil.
Front Med (Lausanne). 2023 Mar 29;10:1138447. doi: 10.3389/fmed.2023.1138447. eCollection 2023.
The incidence of ovarian cancer during pregnancy is low. Most adnexal tumors removed during pregnancy are benign, with ovarian carcinomas found in approximately 1: 10,000-1: 50,000 pregnancies. Literature on this disease is scarce and consists mostly of retrospective studies and case reports. We report the case of a pregnant patient who presented with a primary intestinal-type mucinous adenocarcinoma of the ovary and underwent unilateral salpingo-oophorectomy, with no additional surgical or chemotherapy treatment after the histological diagnosis, despite an infiltrative stromal invasion pattern. To the best of our knowledge, no such case has been previously reported. Conservative treatment in this case of early ovarian carcinoma is possible during pregnancy and should be performed in the Department of Gynecological Oncology and Obstetrics of a tertiary referral hospital. Given the possibility of disease recurrence, such patients require strict clinical oncological surveillance, specialized prenatal care, and assistance from a multidisciplinary team to improve the maternal and perinatal outcomes.
孕期卵巢癌的发病率较低。孕期切除的附件肿瘤大多为良性，卵巢癌在约1:10000 - 1:50000次妊娠中被发现。关于这种疾病的文献稀少，主要包括回顾性研究和病例报告。我们报告一例怀孕患者，其患有原发性卵巢肠型黏液腺癌，接受了单侧输卵管卵巢切除术，尽管存在浸润性间质浸润模式，但在组织学诊断后未进行额外的手术或化疗治疗。据我们所知，此前尚未有此类病例的报道。对于孕期早期卵巢癌的这种情况，保守治疗是可行的，且应在三级转诊医院的妇科肿瘤学和妇产科进行。鉴于疾病复发的可能性，此类患者需要严格的临床肿瘤学监测、专门的产前护理以及多学科团队的协助，以改善孕产妇和围产期结局。
