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在单胺氧化酶氧化苄胺过程中，线粒体内氧化型谷胱甘肽的形成。

Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase.

作者信息

Werner P, Cohen G

机构信息

Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.

出版信息

FEBS Lett. 1991 Mar 11;280(1):44-6. doi: 10.1016/0014-5793(91)80200-m.

DOI:10.1016/0014-5793(91)80200-m
PMID:1901277
Abstract

Oxidation of benzylamine by MAO results in an accumulation of GSSG in mouse liver mitochondria. Formation of GSSG is prevented by deprenyl, an inhibitor of MAO-B, but not by catalase. GSSG accumulation also occurs with dopamine as substrate. Oxidation of monoamines by mitochondrial MAO represents a potential oxidant stress for mitochondria.

摘要

单胺氧化酶（MAO）氧化苄胺会导致小鼠肝线粒体中氧化型谷胱甘肽（GSSG）的积累。MAO-B的抑制剂司来吉兰可防止GSSG的形成，但过氧化氢酶不能。以多巴胺为底物时也会发生GSSG积累。线粒体MAO对单胺的氧化是线粒体潜在的氧化应激。

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Intramitochondrial formation of oxidized glutathione during the oxidation of benzylamine by monoamine oxidase.在单胺氧化酶氧化苄胺过程中，线粒体内氧化型谷胱甘肽的形成。
FEBS Lett. 1991 Mar 11;280(1):44-6. doi: 10.1016/0014-5793(91)80200-m.
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Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow.帕金森病：单胺氧化酶与线粒体电子传递之间的新联系。
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