Ginot L, Fontaine A, Cheymol J, Peyr C
Service Communal d'Hygiène et de Santé, Ville d'Aubervilliers, 31-33, rue Commune-de-Paris, 93300 Aubervilliers.
Rev Epidemiol Sante Publique. 2003 Sep;51(4):427-38.
A multi annual screening and prevention program against lead poisoning was implemented in a suburb of the Paris area. We attempted to assess the effectiveness of this program based on data available from children screening and follow-up.
Indicators of effectiveness included the evolution of blood lead levels at screening and the frequency of secondary increases in blood lead levels. Buildings inclusion dates were used to control for the increasing selection of less exposed children.
A total of 3,660 children were screened between 1992 and 2000. We observed a regular decrease in blood lead levels at screening, in the highest blood lead levels obtained for each child and in the proportion of children whose blood lead levels increased after screening: the proportion of children with initial blood lead levels >=15 micro g/dl fell from 17.4% in the 1992-1996 period to 4.1% in the 1997-2000 period. A multivariate analysis taking into account the first year that children were screened in a given building showed that less exposed children were included over time, but found also an additional independent decrease in blood lead levels that can be related to the effectiveness of prevention efforts. A "building by building" analysis of 30 buildings where more than 20 children were located over the whole study period confirmed that the incidence of lead poisoning decreased within most of these buildings.
Taking into account buildings'inclusion dates makes it possible to distinguish program effectiveness from the consequences of including less exposed children The effectiveness of preventive actions is associated with several interacting factors, including the participation of families and the active involvement of local technical staff and policy makers. The finding that the decrease in blood lead levels leveled off after 1997 calls for further actions.
在巴黎地区的一个郊区实施了一项针对铅中毒的多年筛查与预防计划。我们试图根据儿童筛查和随访获得的数据评估该计划的有效性。
有效性指标包括筛查时血铅水平的变化以及血铅水平二次升高的频率。建筑物纳入日期用于控制对暴露较少儿童的选择增加。
1992年至2000年期间共筛查了3660名儿童。我们观察到筛查时血铅水平、每个儿童获得的最高血铅水平以及筛查后血铅水平升高的儿童比例均呈定期下降:初始血铅水平≥15微克/分升的儿童比例从1992 - 1996年期间的17.4%降至1997 - 2000年期间的4.1%。一项多变量分析考虑了儿童在特定建筑物中首次接受筛查的年份,结果显示随着时间推移纳入了暴露较少的儿童,但也发现血铅水平有额外的独立下降,这可能与预防措施的有效性有关。对整个研究期间有20多名儿童的30栋建筑物进行的“逐栋”分析证实,这些建筑物中的大多数铅中毒发生率有所下降。
考虑建筑物的纳入日期能够区分计划的有效性与纳入暴露较少儿童的后果。预防行动的有效性与多个相互作用的因素相关,包括家庭的参与以及当地技术人员和政策制定者的积极参与。1997年后血铅水平下降趋于平稳这一发现需要进一步采取行动。