中国 2 型糖尿病患者六种相关嘌呤代谢物与糖尿病肾病的相关性
Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
作者信息
Xia Jian-Fei, Liang Qiong-Lin, Hu Ping, Wang Yi-Ming, Li Ping, Luo Guo-An
机构信息
School of Pharmaceutics, East-China University of Science and Technology, China.
出版信息
Clin Biochem. 2009 Feb;42(3):215-20. doi: 10.1016/j.clinbiochem.2008.10.009. Epub 2008 Oct 31.
OBJECTIVES
The assessment of the clinical significance of adenosine, adenine, inosine, xanthine, hypoxanthine and uric acid concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between purine metabolites and disease.
DESIGN AND METHODS
The study group consisted of 119 subjects which were divided into three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23) and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.
RESULTS
There is a significant increase of levels of adenosine (P<0.001), inosine (P<0.001), xanthine (P=0.012) and uric acid (P=0.016) with DN compared to DM. The level of xanthine oxidase (reflected by the uric acid: xanthine) did not change.
CONCLUSION
The levels of adenosine, inosine, uric acid and xanthine may be useful for monitoring the progression of DM and evaluating the treatment.
目的
评估2型糖尿病（T2DM）和糖尿病肾病（DN）患者体内腺苷、腺嘌呤、肌苷、黄嘌呤、次黄嘌呤和尿酸浓度的临床意义，以检测嘌呤代谢物与疾病之间的关系。
设计与方法
研究组由119名受试者组成，分为三组：对照组（n = 31）、无肾病的2型糖尿病组（DM，n = 23）和有肾病的2型糖尿病组（DN，n = 65）。测量了所有参与者血浆中相关代谢物的水平。
结果
与DM组相比，DN组的腺苷水平（P < 0.001）、肌苷水平（P < 0.001）、黄嘌呤水平（P = 0.012）和尿酸水平（P = 0.016）显著升高。黄嘌呤氧化酶水平（以尿酸：黄嘌呤反映）没有变化。
结论
腺苷、肌苷、尿酸和黄嘌呤水平可能有助于监测DM的进展和评估治疗效果。
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