中国 2 型糖尿病患者肌酸及 6 种相关嘧啶代谢物与糖尿病肾病的相关性。
Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
机构信息
School of Pharmaceutics, East-China University of Science and Technology, Shanghai, PR China.
出版信息
Clin Biochem. 2010 Aug;43(12):957-62. doi: 10.1016/j.clinbiochem.2010.05.013. Epub 2010 May 27.
OBJECTIVES
The assessment of the clinical significance of creatine, cytosine, cytidine, uridine, thymine, thymidine, and 2'-deoxyuridine concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between pyrimidine metabolites and disease.
DESIGN AND METHODS
The study group consisted of 119 subjects, which were divided to three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23), and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants.
RESULTS
There is a significant increase in levels of cytosine (P<0.001), cytidine (P<0.001), and thymidine (P=0.016) with DN compared to DM. The levels of uridine, thymine, 2'-deoxyuridine, and creatine did not change.
CONCLUSIONS
The levels of cytosine, cytidine, and thymidine may be useful for monitoring the progression of DM and evaluating the treatment.
目的
评估 2 型糖尿病（T2DM）和糖尿病肾病（DN）患者中肌酸、胞嘧啶、胞苷、尿嘧啶、胸腺嘧啶、胸苷和 2'-脱氧尿苷浓度的临床意义，以检测嘧啶代谢物与疾病之间的关系。
设计和方法
研究组包括 119 名受试者，分为三组：对照组（n=31）、无肾病的 2 型糖尿病（DM，n=23）和伴肾病的糖尿病（DN，n=65）。所有参与者的血浆中均测量了相关代谢物的水平。
结果
与 DM 相比，DN 患者的胞嘧啶（P<0.001）、胞苷（P<0.001）和胸苷（P=0.016）水平显著升高。尿嘧啶、胸腺嘧啶、2'-脱氧尿苷和肌酸水平没有变化。
结论
胞嘧啶、胞苷和胸苷的水平可能有助于监测 DM 的进展和评估治疗效果。
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