Raffaghello Lizzia, Cocco Claudia, Corrias Maria Valeria, Airoldi Irma, Pistoia Vito
Laboratory of Oncology, G. Gaslini Institute, Largo Gerolamo Gaslini 5, 16147 Genova, Italy.
Semin Cancer Biol. 2009 Apr;19(2):97-102. doi: 10.1016/j.semcancer.2008.10.003. Epub 2008 Nov 1.
Chemokines and their receptors have emerged as pivotal regulators of tumour growth, progression, and metastasis. Here we review the current knowledge on chemokines and receptors likely involved in the development of metastasis of neuroectodermal tumours, with emphasis on neuroblastoma. In this respect, we discuss the controversial role of the CXCR4/CXCL12 axis in bone marrow localization of neuroblastoma cells. In addition, we focus on the ability of neuroblastoma-derived chemokines such as CCL2 and CX3CL1 to attract lymphoid cells to the tumour site. Finally, chemokine receptor and function in other neuroectodermal tumours of adulthood (i.e. melanoma and small cell lung cancer) are discussed.
趋化因子及其受体已成为肿瘤生长、进展和转移的关键调节因子。在此，我们综述了目前关于可能参与神经外胚层肿瘤转移发展的趋化因子和受体的知识，重点是神经母细胞瘤。在这方面，我们讨论了CXCR4/CXCL12轴在神经母细胞瘤细胞骨髓定位中的争议性作用。此外，我们关注神经母细胞瘤衍生的趋化因子如CCL2和CX3CL1吸引淋巴细胞至肿瘤部位的能力。最后，还讨论了趋化因子受体及其在其他成人神经外胚层肿瘤（即黑色素瘤和小细胞肺癌）中的功能。
