Gross Nicole, Meier Roland
Pediatric Oncology Research, Department of Pediatrics, University Hospital, Lausanne, Switzerland.
Semin Cancer Biol. 2009 Apr;19(2):103-10. doi: 10.1016/j.semcancer.2008.10.009. Epub 2008 Oct 28.
Although chemokines and their receptors were initially identified as regulators of cell trafficking during inflammation and immune response, they have emerged as crucial players in all stages of tumor development, primary growth, migration, angiogenesis, and establishment as metastases in distant target organs. Neuroectodermal tumors regroup neoplasms originating from the embryonic neural crest cells, which display clinical and biological similarities. These tumors are highly malignant and rapidly progressing diseases that disseminate to similar target organs such as bone marrow, bone, liver and lungs. There is increasing evidence that interaction of several chemokine receptors with corresponding chemokine ligands are implicated in the growth and invasive characteristics of these tumors. In this review we summarize the current knowledge on the role of CXCL12 chemokine and its CXCR4 and CXCR7 receptors in the progression and survival of neuroectodermal tumors, with particular emphasis on neuroblastoma, the most typical and enigmatic neuroectodermal childhood tumor.
尽管趋化因子及其受体最初被确定为炎症和免疫反应期间细胞迁移的调节因子，但它们已成为肿瘤发展、原发性生长、迁移、血管生成以及在远处靶器官中形成转移等所有阶段的关键参与者。神经外胚层肿瘤包括起源于胚胎神经嵴细胞的肿瘤，这些肿瘤表现出临床和生物学上的相似性。这些肿瘤是高度恶性且进展迅速的疾病，会扩散到骨髓、骨骼、肝脏和肺等相似的靶器官。越来越多的证据表明，几种趋化因子受体与相应趋化因子配体的相互作用与这些肿瘤的生长和侵袭特性有关。在本综述中，我们总结了目前关于CXCL12趋化因子及其CXCR4和CXCR7受体在神经外胚层肿瘤进展和存活中的作用的知识，特别强调神经母细胞瘤，这是儿童最典型且最神秘的神经外胚层肿瘤。
