Ohnishi Masayoshi, Fukui Michiaki, Ishikawa Takeshi, Ohnishi Nahoko, Ishigami Noriko, Yoshioka Keiji, Hasegawa Goji, Yoshikawa Toshikazu, Nakamura Naoto
Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Osaka 570-0096, Japan.
Metabolism. 2008 Dec;57(12):1760-4. doi: 10.1016/j.metabol.2008.08.001.
Epidemiologic studies have suggested possible atherogenic roles for such pathogens as Chlamydia pneumoniae, Helicobacter pylori (Hp), cytomegalovirus, and herpes simplex virus. The aim of the present study was to examine the relationship between seropositivity of antibodies to Hp (Hp infection) and arterial stiffness determined by pulse wave velocity (PWV) in 130 patients (73 men and 57 women) with type 2 diabetes mellitus without a history of cardiovascular disease. The prevalence of Hp infection in patients with type 2 diabetes mellitus was 53.8%. Age (66.7 +/- 11.3 vs 60.0 +/- 12.2 years, P = .0014) and systolic blood pressure (138 +/- 19 vs 131 +/- 22 mm Hg, P = .0420) were significantly higher in patients with Hp infection than in those without. Serum C-reactive protein was higher in patients with Hp infection than in those without, although it did not reach statistical significance (0.23 +/- 0.27 vs 0.18 +/- 0.20 mg/dL, P = .2205). Pulse wave velocity was significantly higher in patients with Hp infection than in those without (1877 +/- 550 vs 1585 +/- 331 cm/s, P = .0005). Multiple regression analysis demonstrated that age (beta = .388, P < .0001), mean arterial pressure (beta = .289, P = .0006), hypertensive treatment (beta = .185, P = .0282), and presence of Hp infection (beta = .169, P = .0220) were independent determinants of PWV. In conclusion, Hp infection is associated with arterial stiffness determined by PWV in patients with type 2 diabetes mellitus.
流行病学研究表明，肺炎衣原体、幽门螺杆菌（Hp）、巨细胞病毒和单纯疱疹病毒等病原体可能具有致动脉粥样硬化作用。本研究旨在探讨130例无心血管疾病病史的2型糖尿病患者（73例男性和57例女性）中，抗Hp抗体血清阳性（Hp感染）与通过脉搏波速度（PWV）测定的动脉僵硬度之间的关系。2型糖尿病患者中Hp感染的患病率为53.8%。Hp感染患者的年龄（66.7±11.3岁 vs 60.0±12.2岁，P = 0.0014）和收缩压（138±19 vs 131±22 mmHg，P = 0.0420）显著高于未感染患者。Hp感染患者的血清C反应蛋白高于未感染患者，尽管未达到统计学意义（0.23±0.27 vs 0.18±0.20 mg/dL，P = 0.2205）。Hp感染患者的脉搏波速度显著高于未感染患者（1877±550 vs 1585±331 cm/s，P = 0.0005）。多元回归分析表明，年龄（β = 0.388，P < 0.0001）、平均动脉压（β = 0.289，P = 0.0006）、高血压治疗（β = 0.185，P = 0.0282）和Hp感染的存在（β = 0.169，P = 0.0220）是PWV的独立决定因素。总之，在2型糖尿病患者中，Hp感染与通过PWV测定的动脉僵硬度相关。
