Herderscheê D, Limburg M, Hijdra A, Koster P A
Academisch Medisch Centrum, Amsterdam, The Netherlands.
J Neurol Neurosurg Psychiatry. 1991 Jan;54(1):71-3. doi: 10.1136/jnnp.54.1.71.
Two patients with angiographically proved basilar artery occlusion were treated with systemic recombinant tissue plasminogen activator (rtPA) according to protocol. The first patient was in a locked-in state and gradually deteriorated. On repeat angiography the basilar artery remained occluded. He died and necropsy revealed a pontine haemorrhagic infarction. The second patient, who was comatose and with decerebrate posturing, made a remarkable recovery. Angiography showed reperfusion. Therapy was initiated in the first patient after six hours and in the second after two hours. Treatment with rtPA is promising but probably not feasible for every patient. Success may depend on duration of occlusion and composition of occluding thrombus.
两名经血管造影证实基底动脉闭塞的患者按照方案接受了全身性重组组织型纤溶酶原激活剂（rtPA）治疗。第一名患者处于闭锁状态并逐渐恶化。再次血管造影显示基底动脉仍闭塞。他死亡，尸检发现脑桥出血性梗死。第二名患者昏迷且呈去大脑强直姿势，却有显著恢复。血管造影显示再灌注。第一名患者在6小时后开始治疗，第二名在2小时后开始治疗。rtPA治疗前景光明，但可能并非对每个患者都可行。成功可能取决于闭塞持续时间和闭塞血栓的成分。
